DETERMINATION OF MORPHINE USING MOLECULARLY IMPRINTED POLYMERS BASED ON DIFFERENT MONOMERS
DOI:
https://doi.org/10.36103/mkwd9746Keywords:
solid phase extraction of toxic plants; toxicological analysis, botanical sources, drugsAbstract
This study was aimed to investigate for the particular adsorption of morphine, precipitation polymerization technology was used to create molecularly imprinted polymers. Using benzoyl peroxide as the initiator, ethylene glycol dimethacrylate as the crosslinker, and allyl chloride and styrene as the functional monomers. This MIP demonstrated a maximum morphine adsorption capacity of 38.24 mg/g at a bulk morphine concentration of (20,40,60,80,100) ppm in acetonitrile solution, one of the greatest talents recorded in the literature to date. Thermodynamic analysis, instrumental characterisation, adsorption studies, and suggested mechanisms all verified the molecularly imprinted polymers adsorption capacity, selectivity, reusability, and mechanical and chemical stabilities. FTIR, UV-vis, and scanning electron microscopy were used to monitor the analytes. The range of the relative standard deviations (RSD%) for three measurements made during two patient repeat tests at 20–100 ppm of morphine is (1.587–4.545) %. The range of (102-105) is the relative recoveries obtained for morphine in human urine samples that were spiked.
References
-Al-Bayati. Y. K. 2018. Preparation of selective sensors for cyproheptadine hydrochloride based on molecularly imprinted polymer used n, ndiethylaminoethyl methacrylate as functional monomer. eurasian Journal of Analytical Chemistry.13(5): 2-11. https://doi.org/10.29333/ejac/94233
- Al-Safi A. J. and Y. K. Al-Bayati, 2018. Synthesis and characterization of molecularly imprinted polymer for tramadol HCl using acryl amide and 2-hydroxyethyl meth acrylate as monomers. Current Issues in Pharmacy and Medical Sciences, 31(2) : 81-88. https://doi.org/10.21123/bsj.2018.15.1.0063
-Aljabari, F. I. and Y. K. Al-Bayati. 2021.Estimation of trimethoprim by using a new selective electrode dependent on molecularly imprinted polymers, Egyptian Journal of Chemistry, 64 :6089-6096. https://doi.org/10.21608/EJCHEM.2021.72564.3617.
-Al-Bayati. Y. K. 2023. synthesis, characterization and application of methamphetamine-imprinted polymeric solid-phase.Iraqi Journal of Agricultural Sciences,54(4):11731182. https://doi.org/10.36103/ijas.v54i4.1811
- Al-Bayati, Y. K. and E. A. Hadi. 2022. Synthesis of new molecularly solid-phase used styrene and allyl chloride base functional monomer for determination of cocaine by gc-mass and its clinical applications. Iraqi Journal of Agricultural Sciences, 53(4) :760–766. https://doi.org/10.36103/ijas.v53i4.1586.
- Al-Abbasi. M. A.S., Y. K. Al-Bayati and K.F. Al- Samarrai. 2020. Synthesis of molecularly imprinted Polymers (MIPS) used for the estimation of betamethasone phosphate (BMSP) using different functional monomers. Iraqi Journal of Agricultural Sciences ,51(1):483-492. https://doi.org/10.36103/ijas.v51i1.947
-BelBruno, J. J. 2018. Molecularly imprinted polymers. Chemical reviews, 119(1), 94-119.
- Beike .J, G. Blaschke, A. Mertz, H. Köhler and B. Brinkmann. 1998. A specific immunoassay for the determination of morphine and its glucuronides in human blood.Int J Legal Med.112(1):8-14. https://doi.org/10.1155/2019/7826090.
- Dyary, H. O.; and H. Q. Banaz. 2021. Multidrug resistance of sheep gastrointestinalnematodes in bakrajo district, north Iraq toalbendazole, ivermectin, and levamisole. Iraqi Journal of Agricultural Sciences, 54(3) :730–734. https://doi.org/10.36103/ijas.v52i4.1402.
-Haupt, K., A. V. Linares, M. Bompart, , and B. T. S. 2011. Molecularly imprinted polymers. Molecular imprinting, 1-28.
-Hassan N.M. and Y.K.Al-Bayati.2022. Ionic imprinted polymers IIPs to determination Vanadium (IV) ion in crude and fuel oil. Egyptian Journal of Chemistry. 65(2) :51 – 60. https://doi.org/10.21608/EJCHEM.2021.80139.3952.
- Mehdinia. A. 2010. Preparation and evaluation of solid-phase microextraction fiber based on nano-structured copolymer of aniline and m-amino benzoic acid coating for the analysis of fatty acids in zooplanktons. Journal of Chromatography A.1217:7642–7647. https://doi.org/10.1016/j.chroma.2010.10.031
- Mahdi. A. R., Y. K. Al-Bayati and ST.Ameen. 2019. Preparation of a new molecularly imprinted polymers and its use in the selective extraction for determination bromhexine hydrochloride at pharmaceuticals. Iraqi Journal of Agricultural Sciences, 50(3):886900.https://doi.org/10.36103/ijas.v50i3.705.
Mele, G. S., G. Vasapollo, R. D.Sole , L. Mergola, M. R. Lazzoi, A. Scardino, A., Scorrano. 2011. Molecularly imprinted polymers: present and future prospective. International journal of molecular sciences, 12(9), 5908-5945.
- Moeller ,M. R. S Steinmeyer, and T. Kraemer.1998. Determination of drugs of abuse in blood.J.chromatogr B Biomed Sci Appl, 21(1):91-109. https://doi.org/10.1016/S0378-4347(97)00573-2.
Martín-Esteban, A. and E. Turiel. 2010. Molecularly imprinted polymers for sample preparation: A review. Analytica chimica acta, 668(2), 87-99.
-Nada F. A. , A. Galal and S.H. Hassan .2015. Electrochemical Sensor for morphine based on gold nanoparticles/ ferrocene carboxylic acid/poly (3,4-ethylenediox-ythiophene)composite.International Journal of Electrochemical Science10(3):22652280.https://doi.org/10.1016/S1452-3981(23)04845-9.
- Singleton, V. L. and J. A. Rossi .1965. colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Amer.J.Enology andViticulture, 16: 144-158.DOI:10.5344/ajev.1965.16.3.144.
- Vandenberghe. H. S. M. MacLeod. H. Chinyanga and S. J. Soldin. 1982.Analysis of morphine in serum by high performance liquid chromatography with amperometric detection.National Center for Biotechnology Information.4:3-14. https://doi.org/10.1097/00007691-198208000-00010
- Xiaoqian. Z, M. Chen, G. Cao and G. Hu. 2013. Determination of morphine and codeine in human urine by gas chromatography-mass spectrometry.J anal methods chem. 13: 201-211. https://doi.org/10.1155/2013/151934.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 IRAQI JOURNAL OF AGRICULTURAL SCIENCES
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
How to Cite
2.jpg)
2.jpg)
