CORRELATION BETWEEN SKIN MICROBIAL INFECTION AND IgE, LPS IN SERUM WITH ATOPIC DERMATITIS

Authors

  • Zina M.
  • M. A. AlAubydi

DOI:

https://doi.org/10.36103/ijas.v53i6.1651

Keywords:

atopic dermatitis, IgE, LPS, antimicrobial susceptibility, patients, disease

Abstract

This study was aimed to find the most prevalent microbial isolates, as well as measurement of total serum IgE, LPS levels and their correlation with Atopic dermatitis occurrences. A 88 patients were collected randomly (47 females and 41 males), through a period Sep. 2019 to Feb. 2020 from Al Zafaraniyah General Hospital. Patients ages ranged between 10 months to 30 years. In addition, the control samples are collected randomly from 20 apparently healthy people. Microbial isolation results showed that the most prevalence microbial isolates in atopic skin patients were; Staphylococcus spp. 81 (30.10%), fungi 65 (24.20%), Bacillus spp. 53 (19.70%), Enterobacteriaceae spp. 32 (11.90%), Acinetobacter spp. 16 (5.90%), Corynobacterium spp. 10 (3.70%), Streptococcus spp. 8(3.00%) and Pseudomonas spp. 4 (1.50%) compared with control group. Antimicrobial susceptibility test was carried out for nine antimicrobial agents. The results showed that, most bacterial isolates are become a multidrug resistant especially Staphylococcus spp. and Enterobacteriaceae spp. whilst two other tests in a concern with the AD patients which are IgE and LPS, both parameters results show that, the age from 0 - 2 years, is recorded higher serum level than other age categories.

References

Adam J. SanMiguel; Jacquelyn S. Meisel; Joseph Horwinski and Qi Zheng 2017. Topical antimicrobial treatments can elicit shifts to resident skin bacterial communities and reduce colonization by Staphylococcus aureus competitors. ntimicrobial agents and chemotherapy; 61( 9) 774-717.

Al- shaabani. M.JW.; A.M Al-Ethawi and H.F. AL-Mathkhury 2020. Eco-frienly synthesis of gold nanoparticles and study three effect with antibiotic against Acietobacter BaumanniiI. The Iraqi Journal of Agricultural Science, 51(4):1204-1211.

Ansotegui, I. J. et al. 2020 IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper. World Allergy Organ. J. 13, 100080 .

Aral M.; O. Arican and M. Gul, 2006. The relationship between serum levels of Total IgE, IL-18, IL-12, INF-alfa and Disease severity in children with atopic dermatitis. Mediators Inflamm. (4):73098.

Boguniewicz M and D Y. Leung 2010 Recent insights into atopic dermatitis and implications for management of infectious complications. J Allergy Clin Immunol. 125:4–13.

Chu DM.; J. Ma ; AL. Prince ; KM. Antony; MD. Seferovic and KM. Aagaard 2017. Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery. Nat Med. 23(3):314-326.

Dehlink E; AH. Baker; E. Yen; S. Nurko and E. Fiebiger 2010. Relationships between levels of serum IgE, cell-bound IgE, and IgE receptors on peripheral blood cells in a pediatric population. PLoS One. 5:e12204.

Forthofer R. N. and E.S. Lee 2014. Introduction to biostatistics: guide to design, analysis and discovery. Elsevier print.

Glover T. and K. Mitchell 2008. An introduction to biostatistics. Waveland Press.

Heine H.; E.T. Rietschel and A.J Ulmer 2001. The Biology of Endotoxin. Mol. Biotechnol. 19, 279–296.

Ichiro Katayama; Yoichi Kohno; Kazuo Akiyama; Zenro Ikezawa Naomi Kondo; Kunihiko Tamaki and Osamu Kouro 2011. Japanese Guideline for Atopic Dermatitis. Allergology International 60(2).

Iryohojin Kiyokai, Takayama-shi and Kensuke Kubo 2016 Treatment of atopic dermatitis and infectious dermatitis with biological spa-therapy. United States US Patent Application Publication (10) Pub. No.: US 2016/0089403 A1 Kubo (43) Pub. Date: Mar. 31, 2016

Kirby WM.; AW. Bauer; JC. Sherris; and M. Turck 1966. Antibiotic susceptibility testing by a standardized single disk method. Am J ClinPathol. 45(4):493–496.

Kisich KO; CW Carspecken; S. Fieve; M. Boguniewicz and Leung DY. 2008. Defective killing of Staphylococcus aureus in atopic dermatitis is associated with reduced mobilization of human beta-defensin-3. J Allergy Clin Immunol.;122:62–68.

Kong HH; J. Oh ; C. Deming; S. Conlan; EA. Grice; MA. Beatson; E Nomicos; EC. Polley; HD. Komarow; NISC Comparative Sequence Program; PR. Murray; ML. Turner and JA. Segre 2012. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Res. 22, 850–859.

Kozo Nakai, Yasuo Kubota, and Chie Kohchi 2019. The effect of lipopolysaccharide-containing moisturizing cream on skin care in patients with mild atopic dermatitis. In vivo, 33(1), 109-114.

Maragakis LL and TM. Perl 2008. Acinetobacter baumannii: epidemiology, antimicrobial resistance, and treatment options. Clin Infect Dis. 46(8):1254–1263.

Myles IA; KW. Williams; JD. Reckhow; ML. Jammeh; NB. Pincus; I Sastalla; D Saleem; KD. Stone and SK. Datta 2016. Transplantation of human skin microbiota in models of atopic dermatitis. JCI Insight. 1(10):e86955–e86955.

Nada HA.; NI. Gomaa; A. Elakhras; R. Wasfy and RA. Baker 2012. Skin colonization by superantigen-producing Staphylococcus aureus in egyptian patients with atopic dermatitis and its relation to disease severity and serum interleukin-4 level. Int J Infect Dis 16: 29-33.

Novembre E.; A. Cianferoni and E. Lombardi; et al. 2001. Natural history of intrinsic atopic dermatitis. Allergy., 56:452-453.

Oh J; AL. Byrd and M. Park; NISC Comparative Sequencing Program; HH. Kong and JA. Segre 2016. Temporal Stability of the Human Skin Microbiome. Cell. 5; 165(4):854-66.

Omar, M.M. and H.A., Jabber, 2017. Isolation, screening and identification of bacillus sp producing a alkaline protease. The Iraqi Journal of Agricultural Science; 48(6), :1493-1503.

Ong PY. 2006. Is/are pattern recognition receptor(s) for Staphylococcus aureus defective in atopic dermatitis? Dermatology. 212(1):19–22.

Pickett K; E. Loveman; N. Kalita; GK. Frampton and J Jones 2015. Educational interventions to improve quality of life in people with chronic inflammatory skin diseases: Systematic reviews of clinical effectiveness and cost-effectiveness. Health Technol Assess. 19:1–176.

Prescott L.M.; J.P. Harley and D.A. Klein 2005. Microbiology. 6th ed. The McGraw-Hill Companies, Inc. USA.

Salt BH; M. Boguniewicz and DY. Leung 2007. Severe refractory atopic dermatitis in adults is highly atopic. J Allergy Clin Immunol.;119:508–509.

Scholz CFP and M. Kilian 2016. The natural history of cutaneous propionibacteria, and reclassification of selected species within the genus Propionibacterium to the proposed novel genera Acidipropionibacterium gen. nov., Cutibacterium gen. nov. and Pseudopropionibacterium gen. nov. Int J Syst Evol Microbiol. 66(11):4422-4432.

Slomski A. 2010. Anti-IgE medication lessens pediatric atopic dermatitis severity. JAMA. 25. 323 (8):701.

Tawfiq, S.M., 2018. Bacteriologigal and genetic study of Pseudomonas aeruginosa isolates. Iraqi Journal of Agricultural Sciences,49(1), :27-35.

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Published

2022-12-29

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Articles

How to Cite

M., Z., & AlAubydi, M. A. (2022). CORRELATION BETWEEN SKIN MICROBIAL INFECTION AND IgE, LPS IN SERUM WITH ATOPIC DERMATITIS . IRAQI JOURNAL OF AGRICULTURAL SCIENCES, 53(6), 1358-1367. https://doi.org/10.36103/ijas.v53i6.1651

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