EFFECT OF PARTIAL PURIFIED LOVASTATIN FROM ASPERGILLUS TERREUS A50 ON LIPID PROFILE AND LIVER ENZYMES IN VIVO

Authors

DOI:

https://doi.org/10.36103/ijas.v53i5.1614

Keywords:

lovastatin, lipid profile, liver function, in-vivo.

Abstract

This study was designed to determine the effect of partial purified lovastatin on the lipid profile and liver functions in rabbits. The rabbits were divided into six groups, each group containing four rabbits, and the lipid profile and liver functions were checked at zero, 30, 60, and 90 days. The parameters of the cholesterol, high-density lipoprotein (HDL), triglycerides (TG), low-density lipoprotein (LDL), very- low-density lipoprotein (VLDL), blood bilirubin (BB), and liver enzymes (ALP, ALT and AST) were determined separately. Determination of parameters was made before treatment with any medication and after treatment with cholesterol (4 g/kilo/day), standard lovastatin (0.4 mg/kilo/day), cholesterol plus standard lovastatin 4g+0.4mg/kilo/day), partial purified lovastatin (0.4 mg/kilo/day), and cholesterol plus partial purified lovastatin (4g+0.4mg/kilo/day). The findings showed that partial purified lovastatin have influence on lipid profile and liver function with significant differences (positive effect) (P≤0.05) in the mean of cholesterol, TG, HDL-C, LDL-C, VLDL-C, ALP, ALT, AST and BB levels in compression with the control group, but some of them were higher than the normal value. In addition no significant differences (P≥0.05) in lipid profile and liver function enzymes activity if treatment with standard or partially purified lovastatin.

References

Alenghat, F.J. and A.M. Davis, 2019. Management of blood cholesterol. Jama. 321 (8): 800

Al-Sa’ady, A., and G. Aziz, 2021. Immobilization and application of partial purified lovastatin produced from local isolate Aspergillus terreus A50 using solid state fermentation. Iraqi J. of Agricultural Sci, 52(2): 377-391

Buemi, M., M. Senatore, F. Corica, C. Aloisi, A. Romeo, E. Cavallaro, F. Floccari, D. Tramontana, and N. Frisina, 2002. Statins and progressive renal disease. Medicinal Research Reviews. 22: 76-84

EL-Wakf, M.A., H.A. Ibrahim, H.A. Hassan, H.M. Serag and H.S. Gumaih, 2010. Favorable alteration of cardiovascular disorders with virgin olive oil compared to refined olive oil in atherosclerotic male rats. J. Egypt. Ger. Soc. Zool. 61(A): 25-47.

Garrett, I.R., G.E. Gutierrez, G. Rossini, J. Nyman, B. McCluskey, A. Flores, and G.R. Mundy 2007. Locally delivered lovastatin nanoparticles enhance fracture healing in rats. Journal of Orthopaedic Research. 25: 1351-1357

Hamad, Z.S. and I.H. Mahmood 2007. Comparative effects of lovastatin and simvastatin on liver function tests in hyperlipidaemia plants. The Medical Journal of Basrah University. 25(1): 21-26

Houmard, J.A., N.J. Bruno, R.K. Bruner, M.R. McCammon, R.G Israel and H.A. Barakat, 1994. Effects of exercise training on the chemical composition of plasma LDL. Arteriosclerosis, Thrombosis, and Vascular Biology. 14: 325–330

Kusmana, D., Y. Raflianti, and W. Mangunwardoyo, 2012. The effect of lovastatin produced from Aspergillus flavus UICC 360 on decreasing cholesterol level in blood of rattusnovergicus L.Sprague dawley strain. International Journal of Science and Research. 2(3): 1-5.

Lewington, S., G. Whitlock, R. Clarke, P. Sherliker, J. Emberson, J. Halsey, N. Qizilbash, R. Peto, and R. Collins, 2007. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet. 370 (9602): 1829–39.

Maji, D., S. Shaikh, D. Solanki, and K. Gaurav, 2016. Safety of statins. Indian Journal of Endocrinology and Metabolism. 17(4): 636-647.

Maryam, H., S. Maqsood, A. Jabbar, and A. Ali, 2017. Production of lovastatin from fungal sources and its medical applications. European Journal of Pharmaceutical and Medical Research. 4(6): 148-158

Mouafi, F.E., M.M. Elkomy, and M.M.A. Elsoud, 2016. Optimization of lovastatin production under sub-merged fermentation and its effect on cholesterol blood level in rats. Journal of Innovations in Pharmaceutical and Biological Sciences. 3(4): 33-42.

Novotny, L., and L. Vitek .2003. Inverse relationship between serum bilirubin and atherosclerosis in men: a meta-analysis of published studies. Bulletin of Experimental Biology and Medicine. 228: 568-571

Nurhayati et al. 2019. Protein efficiency in Japanese quail (coturnix-coturnix japonica) fed fermented palm kernel cake by Aspergillus niger. Iraqi J. of Agricultural Sci, 50(2): 377-391

Ohm, T.G. and V. Meske, 2006. Cholesterol and statins. Acta Neurol Scand Suppl, 185: 93-101

Pettit, R. K. 2009. Mixed fermentation for natural product drug discovery. Applied Microbiology and Biotechnology. 83(1): 19-25

Praveen, V.K., S.D. Bhargavi, and J. Savitha, 2015. Lovastatin production by Aspergillus terreus (KM017963) in submerged and solid-state fermentation: A comparative study. American Journal of Pharmacy and Health Research, 3(7): 116-126

Prisant, L.M., M. Downton, L.O. Watkins, H. Schnaper, R.H. Bradford, A.N. Chremos, and A. Langendorfer, 1996. Efficacy and tolerability of lovastatin in 459 African Americans with hyper-cholesterolemia. The American Journal of Medicine. 78: 420-424

Snedecor, G. W. and W.G. Cochran, 1982. Statistical Methods. 7th Ed. The State University Press American, Iowa. 1:677

Taghadosi, M., B.J. Fath-Gharib, and A. Piroozmand, 2013. Comparing the effect of lovastatin and exercise on serum lipid profile in hyperlipidaemia patients. International Journal of Medical and Biomedical Studies. 2(1): 18-32

Taleb, M.H., I.M. Almasri, N.I. Siam, A.A. Najim, and A.I. Ahmed, 2014. The effect of atorvastatin on liver function among patients with coronary heart disease in gaza strip. Pharmacology and Pharmacy. 5: 781-788.

Yassein, S. N., 2020. Comparative study of pathogenicity between Aspergillus fumigatus and Penicillium chrysogenum in mice. Iraqi J. of Agricultural Sci, 51(1):267-283.

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Published

2022-10-25

How to Cite

Al-Sa’ady, A., Aziz, G. M. and Al-Obaidi, M. J. (2022) “EFFECT OF PARTIAL PURIFIED LOVASTATIN FROM ASPERGILLUS TERREUS A50 ON LIPID PROFILE AND LIVER ENZYMES IN VIVO”, IRAQI JOURNAL OF AGRICULTURAL SCIENCES, 53(5), pp. 1003–1010. doi: 10.36103/ijas.v53i5.1614.

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