SYNTHESIS OF NEW MOLECULARLY IMPRINTED SOLID -PHASE UESD STYRENE AND ALLYL CHLORIDE BASE FUNCTIONAL MONOMER FOR DETERMINATION OF COCAINE BY GC-MASS AND ITS CLINICAL APPLICATIONS
Keywords:Cocaine/Molecularly imprinted polymer / styrene / allyl chloride
This study was aimed to synthesize a new molecularly imprinted polymer using a functional monomer of styrene(STY) and allyl chloride(ALC) and N, N-methylene bis-acrylamide (MBAA) as a cross-linker for the selective extraction of cocaine from urine samples. Cocaine is used as a template to create a monolithic solid-phase micro extraction (SPME) fiber. All of these analytical procedures were utilized to extract, preconcentrate, and selectively determine Cocaine and its derivatives (SPME) with gas chromatography and mass spectrometry (GC/MS). Samples taken from a suspected cocaine addict who was given to the medico-legal directorate as a donation (Baghdad, Iraq). The analytes were monitored using UV-Vis , (GC MS), FTIR and Scanning electron microscopy (SEM). The RSD percent for two patients' repeated studies for three measurements range from (1.587-4.545) percent cocaine 20-100 ppm .
Alvear E, D von Baer, C Mardones, Hitschfeld A. Determination of cocaine and its major metabolite benzoylecgonine in several matrices obtained from deceased individuals with presumed drug consumption prior to death. J Forensic Legal Med.;23:37–43. doi:10.1016/j.jflm.2014.01.003
Ali. R. Mahdi, Y. K. Al-Bayati, S. T. Ameen 2019, Preparation of anew molecularly imprinted polymers and its use in the selective extraction for determination Bromhxine Hydrochloride at pharmaceuticals, Iraqi Journal of Agricultural Sciences –2019:50(3):886- 900
Brunetto Mdel R, Y Delgado, S Clavijo, Contreras Y, Torres D, Ayala C, et al. 2010. Analysis of cocaine and benzoylecgonine in urine by using multisyringe flow injection analysis-gas chromatography– mass spectrometry system. J Sep Sci.;33(12):1779–86. doi:10.1002/jssc.200900833
Dowling G, L Regan, J Tierney, and M. A Nangle.2010. Hybrid liquid chromatography-mass spectrometry strategy in a forensic laboratory for opioid, cocaine and amphetamine classes in human urine using a hybrid linear ion trap-triple quadrupole mass spectrometer. J Chromatogr A.; 1217 (44):6857–66. doi:10.1016/j. chroma.2010.08.043
Lerch O, O Temme, and T Daldrup.2014. Comprehensive automation of the solid phase extraction gas chromatographic mass spectrometric analysis (SPE-GC/MS) of opioids, cocaine, and metabolites from serum and other matrices. Anal Bioanal Chem.;406(18): 4443–51. doi:10.1007/s00216-014-7815-7
Langman L. J, M. W. Bjergum, C. L Williamson, and F. W. Crow. 2009. Sensitive method for detection of cocaine and associated analytes by liquid chromatography-tandem mass spectrometry in urine. J Anal Toxicol.;33(8):447–55
Jagerdeo E, M. A. Montgomery, M. Sibum, T.A. Sasaki, and M.A. LeBeau. 2008. Rapid analysis of cocaine and metabolites in urine using a completely automated solid-phase extraction- high- performance liquid chromatography -tandem mass spectrometry method. J Anal Toxicol.;32(8):570–6.
Johansen S. S, and H. M Bhatia 2007. Quantitative analysis of cocaine and its metabolites in whole blood and urine by high-performance liquid chromatography coupled with tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. ;852(1–2): 338–44. doi:10.1016/j.jchromb.2007.01.033.
Muhamed F., A., Yehya and K. Al-Bayati 2019., Determination of methamphetamine by GC-Mass based on molecularly imprinted solid-phase used 2-hydroxy ethyl methacrylate as functional monomer, eurasian Journal of Analytical Chemistry 14 (2): 71-83.
Reid M.J, K.H. Langford, M. Grung, Gjerde H, E.J. Amundsen, J Morland,and et al. 2012Estimation of cocaine consumption in the community: a critical comparison of the results from three complibrsmentary techniques. BMJ Open. 2012; 2(6).doi:10.1136/bmjopen-2012-001637.
Ruiz M. J, D Paolieri, L. S Colzato, and M.T. Bajo. 2015. Chronic and recreational use of cocaine is associated with a vulnerability to semantic interference. Psychopharmacology. 2015;232(10):1717–26.doi:10.1007/s00213-014-3806-9.
Strano-Rossi S, A. M. Bermejo, X. Torre, F. Botre. 2011. Fast GC-MS method for the simultaneous screening of THC-COOH, cocaine, opiates and analogues including buprenorphine and fentanyl, and their metabolites in urine. Anal Bioanal Chem.;399(4):1623– 30. doi:10.1007/s00216-010-4471-4
Valente M. J, F Carvalho, M. L. Bastos, M. Carvalho, and Pinho PGd 2012. Chromatographic Methodologies for Analysis of Cocaine and its Metabolites in Biological Matrices. In: DBS, Editor. Gas Chromatography - Biochemicals, Narcotics and Essential Oils. CC By, pp :163–167. doi:10.5772/32225.
Yaha. K.l Al-Bayati, Muhamed Farhan Abd 2017., Determination of methamphetamine drug by GC-MS based on molecularly imprinted solid-Phase used meth acrylic acid and acryl amide as functional monomers, Journal of Science, Vol. 58, No.4B, pp: 2022.
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