GENETIC VARIABILITY IN THE PRNCR1 GENE AMONG A SAMPLE OF IRAQI PROSTATE CANCER PATIENTS

Authors

  • R.I. Kadhim
  • E. D. Salman

DOI:

https://doi.org/10.36103/ijas.v53i3.1559

Keywords:

cancer, pca patients, case control study, risk factor, PCR technique

Abstract

The PRNCR1 gene variant among sample of Prostate Cancer (PCa) Iraqi patients case-control study was used, with PCa patients (n=32) and healthy individual control (n=33). It was successfully identified two SNPs in prostate cancer-associated noncoding RNA-1 (PRNCR-1) gene by using PCR technique and direct sequencing . The first SNP is rs13252298 (A>G) have three genotypes (AA,AG,GG )and the second SNP is rs5013678 (T> C) have three genotypes TT,TC,CC),these genotype frequencies were not in agreement with Hardy-Weinberg Equilibrium (HWE) in patients and controls .It was observed that AG genotype  was more frequent in patients than controls(68.7% vs. 36.4%) with significant difference p<0.01  ,and the estimated OR of such a difference was 3.85 , this value was positive  associated with PCa patients that mean this genotype AG was risk factor for PCa patients, it was also noticed that  G  allele in PCa patients compared with controls(40.6 vs.33.3%)  show not significant difference p>0.05 . It was revealed  that G  allele have  OR=1.16 that mean this allele have positive risk factor for PCa patients .  In conclusion  AG genotype for SNP rs13252298  was associated with PCa patients.

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Published

2022-06-29

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How to Cite

“GENETIC VARIABILITY IN THE PRNCR1 GENE AMONG A SAMPLE OF IRAQI PROSTATE CANCER PATIENTS” (2022) IRAQI JOURNAL OF AGRICULTURAL SCIENCES, 53(3), pp. 515–521. doi:10.36103/ijas.v53i3.1559.

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