VARIOUS SOLVENT EXTRACTS OF Ipomoea pes-caprae: A PROMISING SOURCE OF NATURAL BIOACTIVE COMPOUNDS COMPARE WITH VITAMIN C

Authors

  • R. A. Islamy
  • V. Hasan
  • N.B. Mamat
  • Y. Kilawati
  • Y. Maimunah

DOI:

https://doi.org/10.36103/5vd4j587

Keywords:

antigenotoxicity, biochemical, GC-MS analysis, micronucleus, gracilaria.

Abstract

This research investigates the phytochemical composition, antioxidant activity, and antibacterial efficacy of Ipomoea pes-caprae extracts collected from Pantai Talang Siring Pamekasan, Madura. Phytochemical analysis revealed the presence of alkaloids, flavonoids, phenolic compounds, terpenoids, tannins, and saponins in the extracts, indicating their rich bioactive profile. Antioxidant activity assessed via the DPPH assay demonstrated concentration-dependent scavenging of free radicals, with methanol and ethanol extracts exhibiting superior activity compared to the aqueous extract. Antibacterial assays against Escherichia coli and Staphylococcus aureus revealed significant inhibitory effects, with methanol and ethanol extracts displaying greater potency than the aqueous extract. These findings underscore the potential of Ipomoea pes-caprae as a source of natural antioxidants and antimicrobial agents, warranting further investigation into its pharmacological applications and therapeutic potential. 

References

Abo-EL-Sooud, K. 2018. Ethnoveterinary Perspectives and Promising Future. International Journal of Veterinary Science and Medicine. https://doi.org/10.1016/j.ijvsm.2018.04.001

Akinniyi, G., J., Lee, H.,Kim, J.,Lee, and I. Yang, 2022. A Medicinal Halophyte Ipomoea Pes-Caprae (Linn.) R. Br.: A Review of Its Botany, Traditional Uses, Phytochemistry, and Bioactivity. Marine Drugs. https://doi.org/10.3390/md20050329

Al-ghanimi, G. M. M., and A. M. Alrubeii. 2024. Effect of elastin hydrolysate on bacteria and some sensory traits of chilled ground beef. Iraqi Journal of Agricultural Sciences, 55(1):422-431. https://doi.org/10.36103/8w3frt36

Al-ghanimi, G. M. M., and A. M. Alrubeii. 2020. Effect of antioxidant potential of astaxanthin and allyl isothiocyanate in quality characteristics of raw ground beef meat during cold storage. Plant Archives, 20, 673–679.

Arif, M., R.,Ullah, M., Ahmad, A., Ali, Z.,Ullah, M., Ali, F. A., Al-Joufi, M., Zahoor, and H.Sher, 2022. Green Synthesis of Silver Nanoparticles Using Euphorbia Wallichii Leaf Extract: Its Antibacterial Action Against Citrus Canker Causal Agent and Antioxidant Potential. Molecules. https://doi.org/10.3390/molecules27113525

Armando, E., A., Lestiyani, and R. A. Islamy, 2021. Potential analysis of lemna sp. extract as immunostimulant to increase non-specific immune response of tilapia (Oreochromis niloticus) against aeromonas hydrophila. Research Journal of Life Science, 8(1), 40–47. https://doi.org/10.21776/ub.rjls.2021.008.01.6

Baldim, I., W. P., de Oliveira, V., Kadian, R., Rao, N., Yadav, S., Mahant, M., Lucarini, A.,Durazzo, R. da, Ana, R., Capasso, S. B., Souto, A., Santini, and E. B. Souto, 2020. Natural Ergot Alkaloids in Ocular Pharmacotherapy: Known Molecules for Novel Nanoparticle-Based Delivery Systems. Biomolecules.pp:310. https://doi.org/10.3390/biom10070980

Braga Gonçalves, F. M., A. C., M. Ramos, da, Silva Mathias, Q. de, Souza Sales, C. C.,Ramos, F.,Antunes, and R. R. de Oliveira, 2020. Phytochemical Analysis and Hypotensive Activity of Ipomoea Pes-Caprae on Blood Pressure of Normotensive Rats. Rodriguésia. https://doi.org/10.1590/2175-7860202071048

Chaieb, K., H., Hajlaoui, T., Zmantar, A. Kahla-Nakbi, M., Ben, Rouabhia, K., Mahdouani, and A. Bakhrouf, 2007. The Chemical Composition and Biological Activity of Clove Essential Oil, Eugenia Caryophyllata Syzigium Aromaticum L. Myrtaceae): A Short Review. Phytotherapy Research. https://doi.org/10.1002/ptr.2124

Escobedo-Martínez, C., S.Cruz-Morales, E., M., Fragoso-Serrano, M. M., Rahman, S., Gibbons, and R. Pereda-Miranda, 2010. Characterization of a Xylose Containing Oligosaccharide, an Inhibitor of Multidrug Resistance in Staphylococcus Aureus, From Ipomoea Pes-Caprae. Phytochemistry. https://doi.org/10.1016/j.phytochem.2010.06.018

Fjingyu L and Y. Z. Z. G. Hanpeng, 2019. Selecting the best individual model to predict potential distribution of Cabomba caroliniana in China. Shengwu Duoyangxing, 27(2), 140–148.

Frey, F. M., and R.Meyers, 2010. Antibacterial Activity of Traditional Medicinal Plants Used by Haudenosaunee Peoples of New York State. BMC Complementary and Alternative Medicine. https://doi.org/10.1186/1472-6882-10-64

Hamad, S., Z. O. Salman, and B. M. J.Alwash, 2021. Assesment of antioxidant and cytotoxic activiy of essential oil extracted from lavandula angustifolia callus leaves. Iraqi Journal of Agricultural Science, 52(6), 1549–1554. https://doi.org/10.36103/ijas.v52i6.1496

Hegazy, M. F., T. A., M. Mohamed, M. A., Atia, A., Shaheen, E. H., Reda, A. I., Elshamy, M., Aziz, and P. W. Paré, 2015. Molecular Architecture and Biomedical Leads of Terpenes From Red Sea Marine Invertebrates. Marine Drugs. https://doi.org/10.3390/md13053154

Islamy, R. A. 2019. Antibacterial activity of cuttlefish sepia sp. (Cephalopoda,) ink extract against aeromonas hydrophila. Majalah Obat Tradisional, 24(3), 184. https://doi.org/10.22146/mot.45315

Islamy, R. A., U., Yanuhar, and A. M. S. Hertika, 2017. Assessing the Genotoxic Potentials of Methomyl-based Pesticide in Tilapia (Oreochromis niloticus) Using Micronucleus Assay. The Journal of Experimental Life Science, 7(2), 88–93. https://doi.org/10.21776/ub.jels.2017.007.02.05

Jiang, M., Wu, Z., H., Guo, L., Liu, and S.Chen, 2020. A Review of Terpenes From Marine-Derived Fungi: 2015–2019. Marine Drugs. https://doi.org/10.3390/md18060321

Kilawati, Y., and R. A. Islamy, 2021. Immunostimulant Activity of Gracilaria sp. and Padina sp. on Immune System of Vannamei Shrimp (Litopenaeus vannamei) Against Vibrio harveyi. Journal of Aquaculture and Fish Health, 10(2), 252. https://doi.org/10.20473/jafh.v10i2.23009

Kozak, L., M., Kokociński, P., Niedzielski, and S.Lorenc, 2015. Bioaccumulation of Metals and Metalloids in Medicinal Plant Ipomoea Pes‐caprae From Areas Impacted by Tsunami. Environmental Toxicology and Chemistry. https://doi.org/10.1002/etc.2794

Kurnia Putri, S. W., D., Nurhasana, A., Avidlyandi, I., Gustian, S., Sipriyadi, and M. Adfa, 2021. Aktivitas Antibakteri Ekstrak Etanol Daun Tapak Kuda (Ipomoea Pes-Caprae (L.) R. Br.) Terhadap Bakteri Staphylococcus Epidermidis. Bioedusains Jurnal Pendidikan Biologi Dan Sains. https://doi.org/10.31539/bioedusains.v4i2.2864

Lazeeza, S. O. 2021. Antioxidant activity of pomegranate. Iraqi Journal of Agricultural Sciences, 52(1), 196–203. https://doi.org/10.36103/ijas.v52i1.1251

Lee, C.T., Y.W., Huang, C.H., Yang, and K.Y. Huang, 2015. Drug Delivery Systems and Combination Therapy by Using Vinca Alkaloids. Current Topics in Medicinal Chemistry. https://doi.org/10.2174/1568026615666150414120547

Lee, W.K., Y.Y., Lim, A. T. C., Leow, P., Namasivayam, J. O., Abdullah, and Ho, C. L. 2017. Biosynthesis of agar in red seaweeds: A review. Carbohydrate Polymers, 164, 23–30. https://doi.org/10.1016/j.carbpol.2017.01.078

Li, C.H., X., Yan, A., Zhang, and J.M.Gao, 2017. Structural Diversity and Biological Activity of the Genus Pieris Terpenoids. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acs.jafc.7b03461

Mc. U., and P.Vijayarengan, 2019. Antimicrobial Activity of Ipomoea Pes-Caprae L. Against Selected Microbial Species. International Journal of Scientific Research in Science and Technology. https://doi.org/10.32628/ijsrst1962134

Matunog, V. E., and L. M. Bajo, 2013. Phytochemical Screening and Antioxidative Potentials of “Beach Morning Glory” Ipomoea Pes- Caprae (Linn.) Roth Leaves Extract. Journal of Multidisciplinary Studies. https://doi.org/10.7828/jmds.v1i1.393

Menna, M., E., Fattorusso, and C.Imperatore, 2011. Alkaloids From Marine Ascidians. Molecules. https://doi.org/10.3390/molecules16108694

Moghadamtousi, S. Z., S., Nikzad, H. A., Kadir, S., AbuBakar, and K.Zandi, 2015. Potential Antiviral Agents From Marine Fungi: An Overview. Marine Drugs. https://doi.org/10.3390/md13074520

Nuskiya, A. 2023. Bioprospecting of Katang-Katang Leaves (Ipomoea Pes-Caprae) From Sumba Island, East Nusa Tenggara: Antimicrobial, Antioxidant and Secondary Metabolites Content. Iop Conference Series Earth and Environmental Science. https://doi.org/10.1088/1755-1315/1260/1/012054

Pereda‐Miranda, R., E., Escalante-Sánchez, and C. Escobedo-Martínez, 2005. Characterization of Lipophilic Pentasaccharides From Beach Morning Glory (Ipomoea es-Caprae). Journal of Natural Products. https://doi.org/10.1021/np0496340

Punithavathi, V. R., R., Anuthama, and P. S. Mainzen Prince, 2008. Combined Treatment With Naringin and Vitamin C Ameliorates Streptozotocin‐induced Diabetes in Male Wistar Rats. Journal of Applied Toxicology. https://doi.org/10.1002/jat.1343

Rajauria, G., Jaiswal, A. K., Abu-Gannam, N., & Gupta, S. 2012. Antimicrobial, antioxidant and free radical-scavenging capacity of brown seaweedhimanthalia elongatafrom western coast of ireland. Journal of Food Biochemistry. https://doi.org/10.1111/j.1745-4514.2012.00663.x

Ramadhani, T., I., Indra, A., Muslim, S., Suhendrayatna, H., Meilina, and S. Saiful, 2020. Adsorption of Cd(II) Ions From Aqueous Solution by a Low-Cost Biosorbent Prepared From Ipomea Pes-Caprae Stem. Aceh International Journal of Science and Technology. https://doi.org/10.13170/aijst.9.3.18256

Russo, E. B. 2011. Taming THC: Potential Cannabis Synergy and Phytocannabinoid‐terpenoid Entourage Effects. British Journal of Pharmacology. https://doi.org/10.1111/j.1476-5381.2011.01238.x

Safrida, S., H., Hasanuddin, and N. A. Agusdinianti, 2019. Effect Extract of Ipomoea Pes-Caprae Leaf as Anti-Inflammatory Non Immunological in Rat Rattus Norvegicus. Aceh Journal of Animal Science. https://doi.org/10.13170/ajas.4.1.12718

Sakna, S. T., Y. R., Maghraby, M. S., Abdelfattah, and M. A. Farag, 2022. Phytochemical Diversity and Pharmacological Effects of Triterpenes From Genus Ziziphus: A Comprehensive Review. Phytochemistry Reviews. https://doi.org/10.1007/s11101-022-09835-y

Sharma, B. D., K., Sharma, Padmashree, S., Rustagi, and K.Awasthi, 2017. Comparative Studies on General Parameters of Flowers and Leaves of Catharanthus Alba and Catharanthus Roseus. Asian Journal of Dairy and Food Research. https://doi.org/10.18805/ajdfr.v36i03.8972

Surowiak, A., L., Balcerzak, S., Lochyński, and D. Strub, 2021. Biological Activity of Selected Natural and Synthetic Terpenoid Lactones. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms22095036

Teramachi, F., Koyano, T., Kowithayakorn, T., M., Hayashi, K., Komiyama, and M. Ishibashi, 2005. Collagenase Inhibitory Quinic Acid Esters From Ipomoea pes-Caprae. Journal of Natural Products. https://doi.org/10.1021/np0500631

Valipour, M., A., Hosseini, A. Di, Sotto, and H. Irannejad, 2023. Dual Action Anti‐inflammatory/Antiviral Isoquinoline Alkaloids as Potent Naturally Occurring anti‐SARS‐CoV‐2 Agents: A Combined Pharmacological and Medicinal Chemistry Perspective. Phytotherapy Research. https://doi.org/10.1002/ptr.7833

Valipour, M., A., Zarghi, M. A., Ebrahimzadeh, and H. Irannejad, 2021. Therapeutic Potential of Chelerythrine as a Multi-Purpose Adjuvant for the Treatment of COVID-19. Cell Cycle. https://doi.org/10.1080/15384101.2021.1982509

Vo, T. P. 2023. Ultrasonic-Assisted and Microwave-Assisted Extraction of Phenolics and Terpenoids From Abelmoschus Sagittifolius (Kurz) Merr Roots Using Natural Deep Eutectic Solvents. Acs Omega. https://doi.org/10.1021/acsomega.3c03929

Wu, F., X., Shi, H., Zou, T., Zhang, X., Dong, R.,Zhu, and C. Y. Yu, 2019. Effects of high-pressure homogenization on physicochemical, rheological and emulsifying properties of myofibrillar protein. Journal of Food Engineering, 263, 272–279. https://doi.org/10.1016/j.jfoodeng.2019.07.009

Yang, Q., Q., Wu, J., Chen, and L.F.Liang, 2022. The Soft Coral Sarcophyton Trocheliophorum: A Warehouse of Terpenoids With Structural and Pharmacological Diversity. Marine Drugs. https://doi.org/10.3390/md21010030

Yazaki, K., G. I., Arimura, and T. Ohnishi, 2017. ‘Hidden’ Terpenoids in Plants: Their Biosynthesis, Localization and Ecological Roles. Plant and Cell Physiology. https://doi.org/10.1093/pcp/pcx123

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Published

2024-10-27

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How to Cite

R. A. Islamy, V. Hasan, N.B. Mamat, Y. Kilawati, & Y. Maimunah. (2024). VARIOUS SOLVENT EXTRACTS OF Ipomoea pes-caprae: A PROMISING SOURCE OF NATURAL BIOACTIVE COMPOUNDS COMPARE WITH VITAMIN C. IRAQI JOURNAL OF AGRICULTURAL SCIENCES, 55(5), 1602-1611. https://doi.org/10.36103/5vd4j587

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